Anesthesia Knowledge Test-6 (AKT-6) Practice Exam 2025 – Complete Study Resource

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What agents are known to cause resistance to non-depolarizing neuromuscular blocking (NMB) agents?

Anticonvulsants such as carbamazepine and phenytoin

Non-depolarizing neuromuscular blocking agents are susceptible to factors that can alter their effectiveness. Anticonvulsants like carbamazepine and phenytoin are known to induce the liver enzymes that lead to an increased metabolism of certain neuromuscular blocking agents. This means that when patients are on these anticonvulsants, there is a greater likelihood that they will require larger doses of non-depolarizing NMB agents to achieve the same level of neuromuscular blockade as those not taking these medications.

The induction of enzymes enhances the clearance of these neuromuscular blockers, leading to a reduced duration of action and potentially inadequate muscle relaxation during anesthesia and surgical procedures. Therefore, the use of anticonvulsants is directly linked to a clinical resistance to the effects of non-depolarizing neuromuscular blockers, warranting awareness and dosage adjustments in affected patients.

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Antibiotics

Anxiolytics

Antihypertensives

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